Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50366262
Substrate
n/a
Meas. Tech.
ChEMBL_201273 (CHEMBL804962)
Ki
2±n/a nM
Citation
 Prucher, H; Gottschlich, R; Haase, A; Stohrer, M; Seyfried, C (5S)-3-aryl-5-(1-piperidinylmethyl)-2-oxazolidinones, a new class of potential neuroleptics with a high affinity for sigma receptors Bioorg Med Chem Lett 2:165-170 (1992)    Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50366262
Synonyms:
CHEMBL417353
Type:
Small organic molecule
Emp. Form.:
C26H30N2O6
Mol. Mass.:
466.5262
SMILES:
OC1(CCN(C[C@H]2CN(C(=O)O2)c2ccc(OCC3CC3)cc2)CC1)c1ccc2OCOc2c1
Structure:
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