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Target
Thermolysin
Ligand
BDBM50035235
Substrate
n/a
Meas. Tech.
ChEBML_210394
IC50
64±n/a nM
Citation
 Bertenshaw, SR; Talley, JJ; Rogers, RS; Carter, JS; Moore, WM; Branson, LM; Koboldt, CM Thiol and hydroxamic acid containing inhibitors of endothelin converting enzyme Bioorg Med Chem Lett 3:1953-1958 (1993)    Article 
Target
Name:
Thermolysin
Synonyms:
THER_BACTH | npr
Type:
PROTEIN
Mol. Mass.:
60097.54
Organism:
Bacillus thermoproteolyticus
Description:
ChEMBL_1468794
Residue:
548
Sequence:
MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLLKVNGTSPEELVYQYVEKNENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTSHVKDGTLTALSGTLIPNLDTKGSLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVYVNGDEASLAYVVNLNFLTPEPGNWLYIIDAVDGKILNKFNQLDAAKPGDVKSITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK
  
Inhibitor
Name:
BDBM50035235
Synonyms:
CHEMBL2372437 | N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydroxy-2-isobutyl-malonamide
Type:
Small organic molecule
Emp. Form.:
C12H22N4O5
Mol. Mass.:
302.3269
SMILES:
CC(C)C[C@H](C(=O)NO)C(=O)N[C@@H](C)C(=O)NCC(N)=O |r|
Structure:
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