Reaction Details
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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Ligand
BDBM50110676
Substrate
n/a
Meas. Tech.
ChEBML_161424
IC50
0.070000±n/a nM
Citation
Quinn, RJ; Taylor, C; Suganuma, M; Fujiki, H The conserved acid binding domain model of inhibitors of protein phosphatases 1 and 2A: Molecular modelling aspects. Bioorg Med Chem Lett 3:1029-1034 (1993) Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Synonyms:
2A5A_HUMAN | PPP2R5A | Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Type:
PROTEIN
Mol. Mass.:
56194.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_161424
Residue:
486
Sequence:
MSSSSPPAGAASAAISASEKVDGFTRKSVRKAQRQKRSQGSSQFRSQGSQAELHPLPQLKDATSNEQQELFCQKLQQCCILFDFMDSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAYSDIVKMISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLESPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEPLFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDDLTSSYKAERQREKKKELEREELWKKLEELKLKKALEKQNSAYNMHSILSNTSAE
Inhibitor
Name:
BDBM50110676
Synonyms:
CHEMBL280487 | okadaic acid
Type:
Small organic molecule
Emp. Form.:
C44H68O13
Mol. Mass.:
805.0029
SMILES:
C[C@@H](C[C@H](O)[C@H]1O[C@@H]2CC[C@@]3(CC[C@@H](O3)\C=C\[C@@H](C)[C@@H]3CC(C)=C[C@@]4(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]4O)O3)O[C@H]2[C@H](O)C1=C)[C@H]1O[C@@]2(CCCCO2)CC[C@H]1C |r,c:23|
Structure:
