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Target
Protein phosphatase 3 catalytic subunit alpha
Ligand
BDBM50285473
Substrate
n/a
Meas. Tech.
ChEBML_42592
Kd
>1000±n/a nM
Citation
 Teague, SJ; Cooper, ME; Stocks, MJ Synthesis of FK506-Cyclosporin hybrid macrocycles Bioorg Med Chem Lett 5:2341-2346 (1995)    Article 
Target
Name:
Protein phosphatase 3 catalytic subunit alpha
Synonyms:
CALNA | CNA | PP2BA_HUMAN | PPP3CA | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | calcineurin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58681.14
Organism:
Homo sapiens (Human)
Description:
calcineurin 0 HUMAN::Q08209
Residue:
521
Sequence:
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
  
Inhibitor
Name:
BDBM50285473
Synonyms:
(8S,10R,18R,19R,22R)-8-Methoxy-10,13,18-trimethyl-14-propyl-19-(2-pyridin-3-yl-ethyl)-20-oxa-5-thia-1,13-diaza-bicyclo[20.3.1]hexacosane-2,3,12,15,21-pentaone | CHEMBL430805
Type:
Small organic molecule
Emp. Form.:
C36H55N3O7S
Mol. Mass.:
673.903
SMILES:
CCCC1N(C)C(=O)C[C@H](C)C[C@@H](CCSCC(=O)C(=O)N2CCC[C@H](C2)C(=O)O[C@H](CCc2cccnc2)[C@H](C)CCC1=O)OC
Structure:
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