Reaction Details Report a problem with these data
Target
Glutamate--cysteine ligase catalytic subunit
Ligand
BDBM50287275
Substrate
n/a
Meas. Tech.
ChEMBL_68752 (CHEMBL681830)
Ki
9230±n/a nM
Citation
 Katoh, M; Hiratake, J; Kato, H; Oda, J Mechanism-based inactivation of E. coli -glutamylcysteine synthetase by phosphinic acid- and sulfoximine-based transition-state analogues Bioorg Med Chem Lett 6:1437-1442 (1996)    Article 
Target
Name:
Glutamate--cysteine ligase catalytic subunit
Synonyms:
GCLC | GLCL | GLCLC | GSH1_HUMAN | Gamma-glutamylcysteine synthetase
Type:
PROTEIN
Mol. Mass.:
72759.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_68753
Residue:
637
Sequence:
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN
  
Inhibitor
Name:
BDBM50287275
Synonyms:
2-ammonio-4-[(2-carboxylatobutyl)sulfonyl]butanoate
Type:
Small organic molecule
Emp. Form.:
C9H16NO6S
Mol. Mass.:
266.292
SMILES:
CCC(CS(=O)(=O)CCC([NH3+])C([O-])=O)C([O-])=O
Structure:
Search PDB for entries with ligand similarity: