Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10A
Ligand
BDBM50287634
Substrate
n/a
Meas. Tech.
ChEBML_47861
IC50
3500±n/a nM
Citation
 Hanson, GJ; Vuletich, JL; Bedell, LJ; Bono, CP; Howard, SC; Welply, JK; Woulfe, SL; Zacheis, ML Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5 Bioorg Med Chem Lett 6:1931-1936 (1996)    Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 10A
Synonyms:
APO2 | CD_antigen=CD261 | DR4 | Death receptor 4 | TNF-related apoptosis-inducing ligand receptor 1 | TNFRSF10A | TR10A_HUMAN | TRAIL receptor 1 | TRAIL receptor-1 | TRAIL-R1 | TRAILR1 | Tumor necrosis factor receptor superfamily member 10A
Type:
PROTEIN
Mol. Mass.:
50092.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_47861
Residue:
468
Sequence:
MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
  
Inhibitor
Name:
BDBM50287634
Synonyms:
(S)-4-[(S)-2-((1S,2R)-1-Carbamoyl-2-hydroxy-propylcarbamoyl)-pyrrolidin-1-yl]-3-({1-[(S)-2-((R)-3-cyclohexyl-butyrylamino)-3-methyl-butyryl]-piperidine-2-carbonyl}-amino)-4-oxo-butyric acid | CHEMBL2373027
Type:
Small organic molecule
Emp. Form.:
C34H56N6O9
Mol. Mass.:
692.8432
SMILES:
CC(C)[C@H](NC(=O)C[C@H](C)C1CCCCC1)C(=O)N1CCCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Structure:
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