Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 10A
Ligand
BDBM50287645
Substrate
n/a
Meas. Tech.
ChEBML_47861
IC50
755±n/a nM
Citation
 Hanson, GJ; Vuletich, JL; Bedell, LJ; Bono, CP; Howard, SC; Welply, JK; Woulfe, SL; Zacheis, ML Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5 Bioorg Med Chem Lett 6:1931-1936 (1996)    Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 10A
Synonyms:
APO2 | CD_antigen=CD261 | DR4 | Death receptor 4 | TNF-related apoptosis-inducing ligand receptor 1 | TNFRSF10A | TR10A_HUMAN | TRAIL receptor 1 | TRAIL receptor-1 | TRAIL-R1 | TRAILR1 | Tumor necrosis factor receptor superfamily member 10A
Type:
PROTEIN
Mol. Mass.:
50092.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_47861
Residue:
468
Sequence:
MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
  
Inhibitor
Name:
BDBM50287645
Synonyms:
1-[(S)-2-(3-Cyclohexyl-propionylamino)-3-methyl-butyryl]-piperidine-2-carboxylic acid ((S)-1-{(S)-2-[(1S,2R)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-pyrrolidine-1-carbonyl}-pentyl)-amide | CHEMBL2373021
Type:
Small organic molecule
Emp. Form.:
C41H71N7O8
Mol. Mass.:
790.0445
SMILES:
CCCC[C@H](NC(=O)[C@@H]1CCCCN1C(=O)[C@@H](NC(=O)CCC1CCCCC1)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O
Structure:
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