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Target
Kynureninase
Ligand
BDBM50288257
Substrate
n/a
Meas. Tech.
ChEBML_91720
Ki
8800±n/a nM
Citation
 Ross, FC; Botting, NP; Leeson, PD Synthesis of phosphinic acid transition state analogues for the reaction catalysed by kynureninase Bioorg Med Chem Lett 6:2643-2646 (1996)    Article 
Target
Name:
Kynureninase
Synonyms:
KYNU | KYNU_HUMAN | L-kynurenine hydrolase
Type:
PROTEIN
Mol. Mass.:
52356.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_91729
Residue:
465
Sequence:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
  
Inhibitor
Name:
BDBM50288257
Synonyms:
(R)-2-Benzyloxycarbonylamino-3-(methoxy-phenyl-phosphinoyl)-propionic acid methyl ester | CHEMBL89851
Type:
Small organic molecule
Emp. Form.:
C19H22NO6P
Mol. Mass.:
391.3548
SMILES:
COC(=O)[C@H](CP(=O)(OC)c1ccccc1)NC(=O)OCc1ccccc1
Structure:
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