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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM50289174
Substrate
n/a
Meas. Tech.
ChEBML_37416
IC50
30±n/a nM
Citation
 Ogawa, S; Ashiura, M; Uchida, C; Watanabe, S; Yamazaki, C; Yamagishi, K; Inokuchi, J Synthesis of potent -D-glucocerebrosidase inhibitors: N-alkyl--valienamines Bioorg Med Chem Lett 6:929-932 (1996)    Article 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM50289174
Synonyms:
(1R,3S,6R)-4-Hydroxymethyl-6-octylamino-cyclohex-4-ene-1,2,3-triol | CHEMBL422734
Type:
Small organic molecule
Emp. Form.:
C15H29NO4
Mol. Mass.:
287.3951
SMILES:
CCCCCCCCNC1C=C(CO)C(O)C(O)C1O |t:10|
Structure:
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