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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM50289177
Substrate
n/a
Meas. Tech.
ChEBML_37416
IC50
300±n/a nM
Citation
 Ogawa, S; Ashiura, M; Uchida, C; Watanabe, S; Yamazaki, C; Yamagishi, K; Inokuchi, J Synthesis of potent -D-glucocerebrosidase inhibitors: N-alkyl--valienamines Bioorg Med Chem Lett 6:929-932 (1996)    Article 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM50289177
Synonyms:
CHEMBL369361 | Hexadecanoic acid {(E)-(1S,2R)-2-hydroxy-1-[((1R,4S,6R)-4,5,6-trihydroxy-3-hydroxymethyl-cyclohex-2-enylamino)-methyl]-heptadec-3-enyl}-amide
Type:
Small organic molecule
Emp. Form.:
C41H78N2O6
Mol. Mass.:
695.0678
SMILES:
CCCCCCCCCCCCCCCC(=O)N[C@@H](CNC1C=C(CO)C(O)C(O)C1O)[C@H](O)\C=C\CCCCCCCCCCCCC |t:22|
Structure:
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