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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM50078114
Substrate
n/a
Meas. Tech.
ChEBML_37416
IC50
1100±n/a nM
Citation
 Ogawa, S; Ashiura, M; Uchida, C; Watanabe, S; Yamazaki, C; Yamagishi, K; Inokuchi, J Synthesis of potent -D-glucocerebrosidase inhibitors: N-alkyl--valienamines Bioorg Med Chem Lett 6:929-932 (1996)    Article 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM50078114
Synonyms:
(1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4,5-tetraol | CHEMBL291020 | Conduritol B Epoxide | Conduritol B Epoxide, 2 | US11826435, Compound 1.2 | US9056847, Conduritol B- epoxide
Type:
Small organic molecule
Emp. Form.:
C6H10O5
Mol. Mass.:
162.1406
SMILES:
O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O
Structure:
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