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Target
Cholesteryl ester transfer protein
Ligand
BDBM50244355
Substrate
n/a
Meas. Tech.
ChEBML_48926
IC50
12900±n/a nM
Citation
 Jeong, T; Ahn, J; Kim, Y; Bok, S; Kwon, B; Shin, J; Seo, Y CETP inhibitory activity of ceramides, isolated from the gorgonian Acabaria Undulata Bioorg Med Chem Lett 7:1481-1482 (1997)    Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50244355
Synonyms:
(2S,3R)-2-amino-1,3-octadecanediol | (2S,3R)-2-aminooctadecane-1,3-diol | (R-(R*,S*))-2-aminooctadecane-1,3-diol | C18-dihydrosphingosine | CHEMBL448741 | D-erythro-1,3-dihydroxy-2-aminooctadecane | D-erythro-2-amino-1,3-octadecanediol | D-erythro-C18-dihydrosphingosine | Safingol | cid_3126 | octadecasphinganine | sphinganine
Type:
Small organic molecule
Emp. Form.:
C18H39NO2
Mol. Mass.:
301.5078
SMILES:
CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO |r|
Structure:
Search PDB for entries with ligand similarity: