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Target
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Ligand
BDBM50289982
Substrate
n/a
Meas. Tech.
ChEMBL_70115 (CHEMBL681650)
Ki
700±n/a nM
Citation
 Turek, TC; Gaon, I; Gamache, D; Distefano, MD Synthesis and evaluation of benzophenone-based photoaffinity labeling analogs of prenyl pyrophosphates containing stable amide linkages Bioorg Med Chem Lett 7:2125-2130 (1997)    Article 
Target
Name:
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Farnesyltransferase | Farnesyltransferase (FTase) | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 70753
Components:
This complex has 2 components.
Component 1
Name:
Protein farnesyltransferase subunit beta
Synonyms:
CAAX farnesyltransferase subunit beta | DPR1 | FNTB_YEAST | FTase-beta | Farnesyltransferase | RAM1 | Ras proteins prenyltransferase subunit beta | SCG2 | STE16
Type:
Protein
Mol. Mass.:
48188.41
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P22007
Residue:
431
Sequence:
MRQRVGRSIARAKFINTALLGRKRPVMERVVDIAHVDSSKAIQPLMKELETDTTEARYKVLQSVLEIYDDEKNIEPALTKEFHKMYLDVAFEISLPPQMTALDASQPWMLYWIANSLKVMDRDWLSDDTKRKIVDKLFTISPSGGPFGGGPGQLSHLASTYAAINALSLCDNIDGCWDRIDRKGIYQWLISLKEPNGGFKTCLEVGEVDTRGIYCALSIATLLNILTEELTEGVLNYLKNCQNYEGGFGSCPHVDEAHGGYTFCATASLAILRSMDQINVEKLLEWSSARQLQEERGFCGRSNKLVDGCYSFWVGGSAAILEAFGYGQCFNKHALRDYILYCCQEKEQPGLRDKPGAHSDFYHTNYCLLGLAVAESSYSCTPNDSPHNIKCTPDRLIGSSKLTDVNPVYGLPIENVRKIIHYFKSNLSSPS
  
Component 2
Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
CAAX farnesyltransferase subunit alpha | FNTA_YEAST | FTase-alpha | Farnesyltransferase | GGTase-I-alpha | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | RAM2 | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha
Type:
PROTEIN
Mol. Mass.:
37495.69
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_588425
Residue:
316
Sequence:
MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN
  
Inhibitor
Name:
BDBM50289982
Synonyms:
Prenyl pyrophosphate analogue
Type:
Small organic molecule
Emp. Form.:
C24H26NO9P2
Mol. Mass.:
534.4137
SMILES:
C\C(CC\C=C(/C)CNC(=O)c1cccc(c1)C(=O)c1ccccc1)=C/COP([O-])(=O)OP([O-])([O-])=O
Structure:
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