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Target
D(2) dopamine receptor
Ligand
BDBM50290212
Substrate
n/a
Meas. Tech.
ChEBML_58455
Ki
17±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50290212
Synonyms:
CHEMBL80315 | Thiophene-2-carboxylic acid (4-{2-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-methyl-amide
Type:
Small organic molecule
Emp. Form.:
C24H31Cl2N3OS
Mol. Mass.:
480.493
SMILES:
CN([C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1)C(=O)c1cccs1 |wU:5.5,wD:2.1,(2.41,-5.51,;3.2,-6.86,;4.74,-6.84,;5.49,-8.17,;7.03,-8.17,;7.81,-6.84,;9.35,-6.83,;10.11,-5.49,;11.65,-5.47,;12.39,-4.11,;13.93,-4.09,;14.73,-5.4,;14,-6.74,;12.46,-6.77,;16.27,-5.37,;17.06,-6.69,;18.6,-6.66,;19.35,-5.3,;18.53,-3.99,;19.28,-2.64,;17,-4.02,;16.2,-2.71,;7.03,-5.51,;5.49,-5.51,;2.43,-8.17,;.89,-8.2,;3.2,-9.52,;4.72,-9.59,;4.58,-12.25,;3.04,-12.16,;2.34,-10.81,)|
Structure:
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