Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50290230
Substrate
n/a
Meas. Tech.
ChEBML_58772
Ki
4.7±n/a nM
Citation
 Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7:2403-2408 (1997)    Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50290230
Synonyms:
CHEMBL309727 | Thiophene-3-carboxylic acid (4-{2-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide
Type:
Small organic molecule
Emp. Form.:
C23H29Cl2N3OS
Mol. Mass.:
466.467
SMILES:
Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3ccsc3)CC2)c1Cl |wU:12.11,wD:15.18,(19.23,-5.96,;18.49,-7.31,;19.3,-8.64,;18.56,-9.99,;17.02,-10.02,;16.22,-8.7,;14.68,-8.73,;13.95,-10.06,;12.41,-10.1,;11.6,-8.8,;10.06,-8.83,;9.31,-10.16,;7.77,-10.17,;6.98,-11.5,;5.44,-11.51,;4.67,-10.18,;5.44,-8.85,;6.98,-8.84,;3.15,-10.18,;2.38,-11.51,;.84,-11.53,;3.1,-12.49,;5.21,-14.12,;4.27,-15.34,;2.74,-15.14,;2.15,-13.7,;12.35,-7.45,;13.89,-7.42,;16.96,-7.36,;16.15,-6.04,)|
Structure:
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