Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50070502
Substrate
n/a
Meas. Tech.
ChEMBL_213031 (CHEMBL816969)
IC50
1760±n/a nM
Citation
 Bajusz, S; Fauszt, I; Németh, K; Barabás, E; Juhász, A; Patthy, M Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases). Bioorg Med Chem Lett 8:1477-82 (1999) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50070502
Synonyms:
((R)-1-Benzyl-2-{(R)-2-[(S)-4-guanidino-1-(2-oxo-ethyl)-butylcarbamoyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-carbamic acid tert-butyl ester | CHEMBL34527
Type:
Small organic molecule
Emp. Form.:
C26H40N6O5
Mol. Mass.:
516.633
SMILES:
CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)CC=O
Structure:
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