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Target
Endothelin-1 receptor
Ligand
BDBM50070876
Substrate
n/a
Meas. Tech.
ChEBML_63346
IC50
6.5±n/a nM
Citation
 Mederski, WW; Dorsch, D; Osswald, M; Anzali, S; Christadler, M; Schmitges, CJ; Schelling, P; Wilm, C; Fluck, M Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. Bioorg Med Chem Lett 8:1771-6 (1999) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50070876
Synonyms:
CHEMBL299328 | Sodium; (Z)-4-benzo[1,3]dioxol-5-yl-2-benzo[1,2,5]thiadiazol-5-yl-4-oxo-3-(3,4,5-trimethoxy-benzyl)-but-2-enoate
Type:
Small organic molecule
Emp. Form.:
C27H21N2O8S
Mol. Mass.:
533.53
SMILES:
COc1cc(C\C(C(=O)c2ccc3OCOc3c2)=C(\C([O-])=O)c2ccc3nsnc3c2)cc(OC)c1OC
Structure:
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