Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50071202
Substrate
n/a
Meas. Tech.
ChEBML_92559
IC50
>10000±n/a nM
Citation
 Horikawa, M; Shigeri, Y; Yumoto, N; Yoshikawa, S; Nakajima, T; Ohfune, Y Syntheses of potent Leu-enkephalin analogs possessing beta-hydroxy-alpha,alpha-disubstituted-alpha-amino acid and their characterization to opioid receptors. Bioorg Med Chem Lett 8:2027-32 (1999) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42692.90
Organism:
Rattus norvegicus (rat)
Description:
P34975
Residue:
380
Sequence:
MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
  
Inhibitor
Name:
BDBM50071202
Synonyms:
(R)-2-[(R)-2-(2-{(S)-2-[(R)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-2-methyl-propionylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid | CHEMBL62688
Type:
Small organic molecule
Emp. Form.:
C30H41N5O8
Mol. Mass.:
599.6752
SMILES:
CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)[C@](C)(CO)NC(=O)[C@H](N)Cc1ccc(O)cc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: