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Target
D(4) dopamine receptor
Ligand
BDBM50071213
Substrate
n/a
Meas. Tech.
ChEMBL_63086 (CHEMBL676182)
IC50
9.00±n/a nM
Citation
 Arlt, M; Böttcher, H; Riethmüller, A; Schneider, G; Bartoszyk, GD; Greiner, H; Seyfried, CA SAR of novel biarylmethylamine dopamine D4 receptor ligands. Bioorg Med Chem Lett 8:2033-8 (1999) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50071213
Synonyms:
2-{4-[5-(4-Fluoro-phenyl)-pyridin-3-ylmethyl]-piperazin-1-yl}-pyrimidine | CHEMBL302183
Type:
Small organic molecule
Emp. Form.:
C20H20FN5
Mol. Mass.:
349.4047
SMILES:
Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2ncccn2)c1
Structure:
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