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Target
Interstitial collagenase
Ligand
BDBM50071832
Substrate
n/a
Meas. Tech.
ChEBML_106288
IC50
703±n/a nM
Citation
 Levin, JI; DiJoseph, JF; Killar, LM; Sung, A; Walter, T; Sharr, MA; Roth, CE; Skotnicki, JS; Albright, JD The synthesis and biological activity of a novel series of diazepine MMP inhibitors. Bioorg Med Chem Lett 8:2657-62 (1999) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50071832
Synonyms:
4-(2-Amino-acetyl)-1-(4-methoxy-benzenesulfonyl)-[1,4]diazepane-2-carboxylic acid hydroxyamide; hydrochloride | CHEMBL252266 | CHEMBL538028
Type:
Small organic molecule
Emp. Form.:
C15H22N4O6S
Mol. Mass.:
386.423
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CCCN(CC1C(=O)NO)C(=O)CN
Structure:
Search PDB for entries with ligand similarity: