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Target
Substance-P receptor
Ligand
BDBM50069864
Substrate
n/a
Meas. Tech.
ChEBML_205567
IC50
0.140000±n/a nM
Citation
 Rosen, TJ; Coffman, KJ; McLean, S; Crawford, RT; Bryce, DK; Gohda, Y; Tsuchiya, M; Nagahisa, A; Nakane, M; Lowe, JA Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist. Bioorg Med Chem Lett 8:281-4 (1999) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50069864
Synonyms:
(5-Chloro-2-methoxy-benzyl)-((2S,3S)-2-phenyl-piperidin-3-yl)-amine | CHEMBL437075
Type:
Small organic molecule
Emp. Form.:
C19H23ClN2O
Mol. Mass.:
330.852
SMILES:
COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1
Structure:
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