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Target
Mu-type opioid receptor
Ligand
BDBM50291697
Substrate
n/a
Meas. Tech.
ChEBML_138996
Ki
>5682±n/a nM
Citation
 Kubota, H; Rothman, RB; Dersch, C; McCullough, K; Pinto, J; Rice, KC Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives. Bioorg Med Chem Lett 8:799-804 (1999) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50291697
Synonyms:
(1S,2S,13S)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.0^{1,13}.0^{2,21}.0^{4,12}.0^{5,10}.0^{19,25}]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-2-ol | Naltrindole analogue
Type:
Small organic molecule
Emp. Form.:
C26H26N2O2
Mol. Mass.:
398.4968
SMILES:
O[C@]12Cc3c([nH]c4ccccc34)[C@H]3Oc4cccc5CC1N(CC1CC1)CC[C@@]23c45 |THB:17:18:1:21.27.26,14:29:1:21.27.26|
Structure:
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