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Target
Neutrophil elastase
Ligand
BDBM50366592
Substrate
n/a
Meas. Tech.
ChEBML_64294
Ki
36700±n/a nM
Citation
 Shi, Y; Sharma, S Metallopeptide approach to the design of biologically active ligands: design of specific human neutrophil elastase inhibitors. Bioorg Med Chem Lett 9:1469-74 (1999) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50366592
Synonyms:
CHEMBL1790152
Type:
Small organic molecule
Emp. Form.:
C38H56N5O9ReS2
Mol. Mass.:
977.216
SMILES:
CC[C@@H](C)C(\NS(=O)(=O)c1ccc(C)cc1)=C(/O)N1[C@@H](CCCCNC(=O)C23CC4CC(CC(C4)C2)C3)C(=O)N2[C@@H](CS[Re]12=O)C(=O)N[C@@H](C(C)C)C(O)=O |TLB:30:31:35:28.29.34,34:33:36:28.29.30,34:29:36:35.33.32,THB:30:29:35:36.31.32|
Structure:
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