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Target
Neutrophil elastase
Ligand
BDBM50366595
Substrate
n/a
Meas. Tech.
ChEBML_64294
Ki
9700±n/a nM
Citation
 Shi, Y; Sharma, S Metallopeptide approach to the design of biologically active ligands: design of specific human neutrophil elastase inhibitors. Bioorg Med Chem Lett 9:1469-74 (1999) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50366595
Synonyms:
CHEMBL1790148
Type:
Small organic molecule
Emp. Form.:
C38H56N5O7ReS
Mol. Mass.:
913.153
SMILES:
CC[C@@H](C)C(\NCc1ccccc1)=C(/O)N1[C@@H](CCCCNC(=O)C23CC4CC(CC(C4)C2)C3)C(=O)N2[C@@H](CS[Re]12=O)C(=O)N[C@@H](C(C)C)C(O)=O |TLB:31:30:33:25.26.27,31:26:33:32.30.29,27:28:32:25.26.31,THB:27:26:32:33.28.29|
Structure:
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