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Target
Arginine--tRNA ligase, cytoplasmic
Ligand
BDBM50091515
Substrate
n/a
Meas. Tech.
ChEBML_36050
IC50
4.5±n/a nM
Citation
 Forrest, AK; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ; Sheppard, RJ Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases. Bioorg Med Chem Lett 10:1871-4 (2000) [PubMed]  Article 
Target
Name:
Arginine--tRNA ligase, cytoplasmic
Synonyms:
ArgRS | Arginine--tRNA ligase | Arginyl-tRNA synthetase | Arginyl-tRNA synthetase, cytoplasmic | RARS | RARS1 | SYRC_HUMAN
Type:
PROTEIN
Mol. Mass.:
75379.14
Organism:
Homo sapiens (Human)
Description:
ChEMBL_36050
Residue:
660
Sequence:
MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRKSLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMGISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM
  
Inhibitor
Name:
BDBM50091515
Synonyms:
Aminoalkyl adenylate and aminoacyl sulfamate analogue
Type:
Small organic molecule
Emp. Form.:
C16H27N10O7S
Mol. Mass.:
503.513
SMILES:
N[C@@H](CCCNC(N)=[NH2+])C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
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