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Target
Glutamine--tRNA ligase
Ligand
BDBM50366673
Substrate
n/a
Meas. Tech.
ChEMBL_72304 (CHEMBL688462)
Ki
3000±n/a nM
Citation
 Bernier, S; Dubois, DY; Therrien, M; Lapointe, J; Chênevert, R Synthesis of glutaminyl adenylate analogues that are inhibitors of glutaminyl-tRNA synthetase. Bioorg Med Chem Lett 10:2441-4 (2001) [PubMed]  Article 
Target
Name:
Glutamine--tRNA ligase
Synonyms:
Glutaminyl-tRNA synthetase | QARS | QARS1 | SYQ_HUMAN
Type:
PROTEIN
Mol. Mass.:
87806.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_72305
Residue:
775
Sequence:
MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLASRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPEQIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPKLEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVESLEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASLHVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV
  
Inhibitor
Name:
BDBM50366673
Synonyms:
CHEMBL608302
Type:
Small organic molecule
Emp. Form.:
C15H21N6O9P
Mol. Mass.:
460.3358
SMILES:
NC(CCC(O)=O)C(=O)OP(O)(=O)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
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