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Target
M-phase inducer phosphatase 2
Ligand
BDBM50068035
Substrate
n/a
Meas. Tech.
ChEBML_49032
IC50
19000±n/a nM
Citation
 Takahashi, M; Dodo, K; Sugimoto, Y; Aoyagi, Y; Yamada, Y; Hashimoto, Y; Shirai, R Synthesis of the novel analogues of dysidiolide and their structure-activity relationship. Bioorg Med Chem Lett 10:2571-4 (2001) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50068035
Synonyms:
(S)-5-Hydroxy-4-{(S)-1-hydroxy-2-[(1S,2S,5R,8aR)-1,2,5-trimethyl-5-(4-methyl-pent-4-enyl)-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-yl]-ethyl}-5H-furan-2-one | 5-Hydroxy-4-{1-hydroxy-2-[1,2,5-trimethyl-5-(4-methyl-pent-4-enyl)-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-yl]-ethyl}-5H-furan-2-one(dysidiolide) | CHEMBL356927
Type:
Small organic molecule
Emp. Form.:
C25H38O4
Mol. Mass.:
402.5668
SMILES:
C[C@H]1CC=C2[C@H](CCC[C@]2(C)CCCC(C)=C)[C@@]1(C)C[C@H](O)C1=CC(=O)O[C@@H]1O |c:3,t:24|
Structure:
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