Reaction Details Report a problem with these data
Target
M-phase inducer phosphatase 1
Ligand
BDBM50093974
Substrate
n/a
Meas. Tech.
ChEBML_49010
IC50
13000±n/a nM
Citation
 Takahashi, M; Dodo, K; Sugimoto, Y; Aoyagi, Y; Yamada, Y; Hashimoto, Y; Shirai, R Synthesis of the novel analogues of dysidiolide and their structure-activity relationship. Bioorg Med Chem Lett 10:2571-4 (2001) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM50093974
Synonyms:
5-Hydroxy-4-{(S)-1-hydroxy-2-[(1S,2R,5S,8aS)-1,2,5-trimethyl-5-(4-methyl-pent-4-enyl)-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-yl]-ethyl}-5H-furan-2-one | CHEMBL86406
Type:
Small organic molecule
Emp. Form.:
C25H38O4
Mol. Mass.:
402.5668
SMILES:
C[C@@H]1CC=C2[C@@H](CCC[C@@]2(C)CCCC(C)=C)[C@@]1(C)C[C@H](O)C1=CC(=O)OC1O |c:3,t:24|
Structure:
Search PDB for entries with ligand similarity: