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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50085507
Substrate
n/a
Meas. Tech.
ChEBML_142803
IC50
110±n/a nM
Citation
 Tamiz, AP; Smith, MP; Kozikowski, AP Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine. Bioorg Med Chem Lett 10:297-300 (2000) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50085507
Synonyms:
(1R,3S)-3-p-Tolyl-7-aza-tricyclo[5.3.0.0*4,8*]decan-5-one | CHEMBL102018
Type:
Small organic molecule
Emp. Form.:
C16H19NO
Mol. Mass.:
241.3282
SMILES:
Cc1ccc(cc1)[C@H]1C[C@H]2CCC3C1C(=O)CN23 |TLB:10:9:12:14.16,THB:16:17:13.7.8:11.10,4:7:12:14.16|
Structure:
Search PDB for entries with ligand similarity: