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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50085584
Substrate
n/a
Meas. Tech.
ChEBML_154201
EC50
190±n/a nM
Citation
 Yanagisawa, H; Takamura, M; Yamada, E; Fujita, S; Fujiwara, T; Yachi, M; Isobe, A; Hagisawa, Y Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship. Bioorg Med Chem Lett 10:373-5 (2000) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50085584
Synonyms:
5-(4-{2-[1-(6-Phenyl-pyridin-3-yl)-eth-(E)-ylideneaminooxy]-ethoxy}-benzyl)-thiazolidine-2,4-dione | CHEMBL123749
Type:
Small organic molecule
Emp. Form.:
C25H23N3O4S
Mol. Mass.:
461.533
SMILES:
C\C(=N/OCCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccc(nc1)-c1ccccc1
Structure:
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