Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50100092
Substrate
n/a
Meas. Tech.
ChEBML_106309
IC50
>30000±n/a nM
Citation
 Baxter, AD; Bhogal, R; Bird, J; Keily, JF; Manallack, DT; Montana, JG; Owen, DA; Pitt, WR; Watson, RJ; Wills, RE Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors. Bioorg Med Chem Lett 11:1465-8 (2001) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50100092
Synonyms:
2-(4-Benzyl-benzenesulfonylmethyl)-5-phenyl-pentanoic acid hydroxyamide | CHEMBL34353
Type:
Small organic molecule
Emp. Form.:
C25H27NO4S
Mol. Mass.:
437.551
SMILES:
ONC(=O)C(CCCc1ccccc1)CS(=O)(=O)c1ccc(Cc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: