Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50100954
Substrate
n/a
Meas. Tech.
ChEBML_152574
Ki
16000±n/a nM
Citation
 Grunewald, GL; McLeish, MJ; Criscione, KR Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme. Bioorg Med Chem Lett 11:1579-82 (2001) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM50100954
Synonyms:
5-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-9-ylamine | CHEMBL35982
Type:
Small organic molecule
Emp. Form.:
C12H12F3N
Mol. Mass.:
227.2256
SMILES:
NC1C2CCC1c1c2cccc1C(F)(F)F |TLB:0:1:6.7:4.3,8:7:1:4.3,THB:11:6:1:4.3|
Structure:
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