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Target
D(1A) dopamine receptor
Ligand
BDBM50104344
Substrate
n/a
Meas. Tech.
ChEBML_60342
Ki
3500±n/a nM
Citation
 Einsiedel, J; Hübner, H; Gmeiner, P Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179). Bioorg Med Chem Lett 11:2533-6 (2001) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
D(1A) dopamine receptor | D1AR | DOPAMINE D1 | DRD1 | DRD1_BOVIN | Dopamine receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49330.65
Organism:
BOVINE
Description:
DOPAMINE D1 DRD1 BOVINE::Q95136
Residue:
446
Sequence:
MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50104344
Synonyms:
1-[(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-ylmethyl]-4-phenyl-piperazine | CHEMBL315564
Type:
Small organic molecule
Emp. Form.:
C22H26BrN3O2
Mol. Mass.:
444.365
SMILES:
COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(CC2)c2ccccc2)[C@@H](C)O1 |t:10|
Structure:
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