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Target
Histone deacetylase
Ligand
BDBM50366731
Substrate
n/a
Meas. Tech.
ChEBML_79057
IC50
4±n/a nM
Citation
 Colletti, SL; Myers, RW; Darkin-Rattray, SJ; Gurnett, AM; Dulski, PM; Galuska, S; Allocco, JJ; Ayer, MB; Li, C; Lim, J; Crumley, TM; Cannova, C; Schmatz, DM; Wyvratt, MJ; Fisher, MH; Meinke, PT Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2. Bioorg Med Chem Lett 11:113-7 (2001) [PubMed]  Article 
Target
Name:
Histone deacetylase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
50433.01
Organism:
Cryptosporidium parvum
Description:
ChEMBL_79057
Residue:
444
Sequence:
MAKRVSYFYDGDIGSYYYGPGHPMKPQRIRMAHNLILSYDLYKHMEIYKPHKSPQSELVYFHEEDYINFLSSINPDNSKDFGLQLKRFNLGETTDCPVFDGLFEFQQICAGGSIDGAYKLNNEQSDICINWSGGLHHAKRSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYLSHRVLTVSFHKFGEFFPGTGDITDIGVAQGKYYSVNVPLNDGIDDDSFLSLFKPIISKCIEVYRPGAIVLQCGADSVRGDRLGRFNLSIKGHAECVEFCKKFNIPLLILGGGGYTIRNVARTWAYETATILDRTDLISDNIPLNDYYDYFAPDFKLHIPPLNLPNMNSPEHLEKIKAKVIDNLRYLEHAPGVEFAYVPSDFFDREASNLQKQEDEEREEELSSWQGGGRAAGSTESQGNHNEKPKSSRKLQKEHASEFY
  
Inhibitor
Name:
BDBM50366731
Synonyms:
CHEMBL1793990
Type:
Small organic molecule
Emp. Form.:
C36H51N5O6
Mol. Mass.:
649.82
SMILES:
CCCn1cc(C(O)c2nc(O)c(CCCCCC(=O)CC)[nH]c(O)c3CCCCn3c(O)c([nH]c2=O)[C@@H](C)CC)c2ccccc12
Structure:
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