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Target
Steryl-sulfatase
Ligand
BDBM50051829
Substrate
n/a
Meas. Tech.
ChEBML_67985
IC50
2600±n/a nM
Citation
 Jütten, P; Schumann, W; Härtl, A; Heinisch, L; Gräfe, U; Werner, W; Ulbricht, H A novel type of nonsteroidal estrone sulfatase inhibitors. Bioorg Med Chem Lett 12:1339-42 (2002) [PubMed]  Article 
Target
Name:
Steryl-sulfatase
Synonyms:
ARSC1 | ASC | Arylsulfatase C | STS | STS_HUMAN | Steroid sulfatase | Steryl-sulfate sulfohydrolase
Type:
Enzyme
Mol. Mass.:
65503.66
Organism:
Homo sapiens (Human)
Description:
P08842
Residue:
583
Sequence:
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
  
Inhibitor
Name:
BDBM50051829
Synonyms:
4-methyl-2-oxo-2H-chromen-7-yl sulfamate | CHEMBL11185 | Sulfamic acid 4-methyl-2-oxo-2H-chromen-7-yl ester
Type:
Small organic molecule
Emp. Form.:
C10H9NO5S
Mol. Mass.:
255.247
SMILES:
Cc1cc(=O)oc2cc(OS(N)(=O)=O)ccc12
Structure:
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