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Target
4-hydroxyphenylpyruvate dioxygenase
Ligand
BDBM50124366
Substrate
n/a
Meas. Tech.
ChEMBL_541 (CHEMBL857062)
IC50
40±n/a nM
Citation
 Huang, M; Yang, DY; Shang, Z; Zou, J; Yu, Q 3D-QSAR studies on 4-hydroxyphenylpyruvate dioxygenase inhibitors by comparative molecular field analysis (CoMFA). Bioorg Med Chem Lett 12:2271-5 (2002) [PubMed]  Article 
Target
Name:
4-hydroxyphenylpyruvate dioxygenase
Synonyms:
HPD | HPPD_PIG
Type:
PROTEIN
Mol. Mass.:
45064.25
Organism:
Sus scrofa
Description:
ChEMBL_541
Residue:
393
Sequence:
MTSYSDKGEKPERGRFLHFHSVTFWVGNAKQAASYYCSKIGFEPLAYKGLETGSREVVSHVVKQDKIVFVFSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAIIVREEVCCAADVRGHHTPLDRARQVWEGTLVEKMTFCLDSRPQPSQTLLHRLLLSKLPKCGLEIIDHIVGNQPDQEMESASQWYMRNLQFHRFWSVDDTQIHTEYSALRSVVMANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRSLRERGVEFLAVPFTYYKQLQEKLKSAKIRVKESIDVLEELKILVDYDEKGYLLQIFTKPMQDRPTVFLEVIQRNNHQGFGAGNFNSLFKAFEEEQELRGNLTDTDPNGVPFRL
  
Inhibitor
Name:
BDBM50124366
Synonyms:
4-Cyclopropanecarbonyl-3-cyclopropanecarbonyloxy-5-oxo-cyclohex-3-enecarboxylic acid ethyl ester | CHEMBL308262
Type:
Small organic molecule
Emp. Form.:
C17H20O6
Mol. Mass.:
320.3371
SMILES:
CCOC(=O)C1CC(=O)C(C(=O)C2CC2)=C(C1)OC(=O)C1CC1 |c:15|
Structure:
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