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Target
Beta-lactamase TEM
Ligand
BDBM50112051
Substrate
n/a
Meas. Tech.
ChEBML_47839
IC50
32000±n/a nM
Citation
 Copar, A; Prevec, T; Anzic, B; Mesar, T; Selic, L; Vilar, M; Solmajer, T Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors. Bioorg Med Chem Lett 12:971-5 (2002) [PubMed]  Article 
Target
Name:
Beta-lactamase TEM
Synonyms:
BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla
Type:
Enzyme
Mol. Mass.:
31512.33
Organism:
Escherichia coli
Description:
P62593
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM50112051
Synonyms:
CHEMBL175015 | Sodium; (S)-2-eth-(E)-ylidene-1-oxo-2,2a,2b,3,5,6-hexahydro-1H-4-thia-7a-aza-cyclobuta[a]indene-7-carboxylate
Type:
Small organic molecule
Emp. Form.:
C12H12NO3S
Mol. Mass.:
250.294
SMILES:
C\C=C1/[C@@H]2C3CSCCC3=C(N2C1=O)C([O-])=O |c:10|
Structure:
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