Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50112054
Substrate
n/a
Meas. Tech.
ChEMBL_162019 (CHEMBL764870)
Ki
1480000±n/a nM
Citation
 Alvarez, F; Ghérardi, A; Nebois, P; Sarciron, ME; Pétavy, AF; Walchshofer, N Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase. Bioorg Med Chem Lett 12:977-9 (2002) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50112054
Synonyms:
1-(2-Fluoro-benzyl)-1H-benzoimidazole-4,7-dione | CHEMBL367662
Type:
Small organic molecule
Emp. Form.:
C14H9FN2O2
Mol. Mass.:
256.2319
SMILES:
Fc1ccccc1Cn1cnc2c1C(=O)C=CC2=O |c:17|
Structure:
Search PDB for entries with ligand similarity: