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Target
Carbonic anhydrase 4
Ligand
BDBM50094392
Substrate
n/a
Meas. Tech.
ChEBML_45273
Ki
8±n/a nM
Citation
 Abbate, F; Casini, A; Owa, T; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett 14:217-23 (2003) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM50094392
Synonyms:
2,3,4,5,6-Pentafluoro-N-(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidene)-benzamide | 2,3,4,5,6-Pentafluoro-N-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidene]-benzamide | CHEMBL69149
Type:
Small organic molecule
Emp. Form.:
C10H5F5N4O3S2
Mol. Mass.:
388.294
SMILES:
Cn1nc(s\c1=N\C(=O)c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O
Structure:
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