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Target
Nociceptin receptor
Ligand
BDBM50140740
Substrate
n/a
Meas. Tech.
ChEBML_144661
Ki
1054±n/a nM
Citation
 Chen, Z; Goehring, RR; Valenzano, KJ; Kyle, DJ Design and synthesis of novel small molecule N/OFQ receptor antagonists. Bioorg Med Chem Lett 14:1347-51 (2004) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50140740
Synonyms:
(3aR,7aR)-1-(1-Benzyl-piperidin-4-yl)-octahydro-benzoimidazol-2-one | CHEMBL26521
Type:
Small organic molecule
Emp. Form.:
C19H27N3O
Mol. Mass.:
313.4372
SMILES:
O=C1N[C@@H]2CCCC[C@H]2N1C1CCN(Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: