Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50137629
Substrate
n/a
Meas. Tech.
ChEBML_70678
pH
7.4±n/a
Ki
6300±n/a nM
Comments
extracted
Citation
 Fu, M; Silverman, RB Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism. Bioorg Med Chem Lett 14:203-6 (2003) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
Abat | GABT_RAT | Gabat | Gamma-amino-N-butyrate transaminase
Type:
PROTEIN
Mol. Mass.:
56465.74
Organism:
Rattus norvegicus
Description:
ChEMBL_884621
Residue:
500
Sequence:
MAFLLTTRRLVCSSQKNLHLFTPGSRYISQAAAKVDFEFDYDGPLMKTEVPGPRSQELMKQLNTIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFVDKLRESLMSVAPKGMCQLITMACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVTDNQQEEARCLEEVEDLIVKYRKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMSFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNVAHAGKTLLTGLLDLQAQYPQFVSRVRGRGTFCSFDTPDEAIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSGILADFK
  
Inhibitor
Name:
BDBM50137629
Synonyms:
4-Amino-4,5-dihydro-furan-2-carboxylic acid anion
Type:
Small organic molecule
Emp. Form.:
C5H6NO3
Mol. Mass.:
128.1066
SMILES:
NC1COC(=C1)C([O-])=O |c:4|
Structure:
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