Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50027355
Substrate
n/a
Meas. Tech.
ChEBML_196269
Ki
2200±n/a nM
Citation
 Ondetti, MA; Cushman, DW Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem 24:355-61 (1981) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50027355
Synonyms:
2-[2-(Hydroxy-phenoxy-phosphorylamino)-3-phenyl-propionylamino]-propionic acid | CHEMBL331117
Type:
Small organic molecule
Emp. Form.:
C18H21N2O6P
Mol. Mass.:
392.3429
SMILES:
C[C@@H](NC(=O)[C@H](Cc1ccccc1)NP(O)(=O)Oc1ccccc1)C(O)=O
Structure:
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