Reaction Details Report a problem with these data
Target
Neprilysin
Ligand
BDBM50139892
Substrate
n/a
Meas. Tech.
ChEBML_64504
IC50
1000±n/a nM
Citation
 Fournié-Zaluski, MC; Chaillet, P; Soroca-Lucas, E; Marçais-Collado, H; Costentin, J; Roques, BP New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties. J Med Chem 26:60-5 (1983) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_MOUSE
Type:
PROTEIN
Mol. Mass.:
85694.36
Organism:
Mus musculus
Description:
ChEMBL_144448
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLKLLPDIYGWPVASDNWDQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
  
Inhibitor
Name:
BDBM50139892
Synonyms:
(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-propionic acid | (S,S)2-(2-phenyl-1-trimethylammonioethylcarboxamido)propanoate | CHEMBL429950 | Phe-Ala
Type:
Small organic molecule
Emp. Form.:
C12H16N2O3
Mol. Mass.:
236.267
SMILES:
C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: