Reaction Details Report a problem with these data
Target
Cytosol aminopeptidase
Ligand
BDBM50027041
Substrate
n/a
Meas. Tech.
ChEMBL_98402 (CHEMBL706599)
Ki
120±n/a nM
Citation
 Rich, DH; Moon, BJ; Harbeson, S Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes. J Med Chem 27:417-22 (1984) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_HUMAN | Aminopeptidase | LAP3 | LAPEP | Leucine aminopeptidase | PEPS
Type:
PROTEIN
Mol. Mass.:
56171.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507539
Residue:
519
Sequence:
MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA
  
Inhibitor
Name:
BDBM50027041
Synonyms:
2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-4-methyl-pentanoic acid | CHEMBL1689155
Type:
Small organic molecule
Emp. Form.:
C13H26N2O4
Mol. Mass.:
274.3565
SMILES:
CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](CC(C)C)C(O)=O |r|
Structure:
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