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Target
Adenosylhomocysteinase
Ligand
BDBM50026329
Substrate
n/a
Meas. Tech.
ChEBML_197214
Ki
22000±n/a nM
Citation
 Houston, DM; Dolence, EK; Keller, BT; Patel-Thombre, U; Borchardt, RT Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 9. 2',3'-Dialdehyde derivatives of carbocyclic purine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem 28:471-7 (1985) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50026329
Synonyms:
3-(7-Amino-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-hydroxymethyl-cyclopentane-1,2-diol | 3-(7-amino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-hydroxymethyl-1,2-cyclopentanediol | CHEMBL26801
Type:
Small organic molecule
Emp. Form.:
C10H14N6O3
Mol. Mass.:
266.2566
SMILES:
Nc1ncnc2n(nnc12)C1CC(CO)C(O)C1O
Structure:
Search PDB for entries with ligand similarity: