Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50025230
Substrate
n/a
Meas. Tech.
ChEBML_153307
Ki
108000±n/a nM
Citation
 Grunewald, GL; Arrington, HS; Bartlett, WJ; Reitz, TJ; Sall, DJ Binding requirements of phenolic phenylethylamines in the benzonorbornene skeleton at the active site of phenylethanolamine N-methyltransferase. J Med Chem 29:1972-82 (1986) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50025230
Synonyms:
9-Amino-1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-ol | CHEMBL61551
Type:
Small organic molecule
Emp. Form.:
C11H13NO
Mol. Mass.:
175.227
SMILES:
N[C@@H]1C2CCC1c1cc(O)ccc21 |TLB:11:12:1:4.3,7:6:1:4.3,0:1:6.12:4.3|
Structure:
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