Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50024839
Substrate
n/a
Meas. Tech.
ChEBML_153307
Ki
304000±n/a nM
Citation
 Grunewald, GL; Arrington, HS; Bartlett, WJ; Reitz, TJ; Sall, DJ Binding requirements of phenolic phenylethylamines in the benzonorbornene skeleton at the active site of phenylethanolamine N-methyltransferase. J Med Chem 29:1972-82 (1986) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50024839
Synonyms:
2-Amino-1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-ol | CHEMBL61749
Type:
Small organic molecule
Emp. Form.:
C11H13NO
Mol. Mass.:
175.227
SMILES:
N[C@@H]1CC2CC1c1ccc(O)cc21 |TLB:0:1:6.12:4,THB:7:6:4:1.2,11:12:4:1.2|
Structure:
Search PDB for entries with ligand similarity: