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Target
Renin
Ligand
BDBM50024165
Substrate
n/a
Meas. Tech.
ChEMBL_154892 (CHEMBL763034)
IC50
47±n/a nM
Citation
Guégan, R; Diaz, J; Cazaubon, C; Beaumont, M; Carlet, C; Clément, J; Demarne, H; Mellet, M; Richaud, JP; Segondy, D Pepstatin analogues as novel renin inhibitors. J Med Chem 29:1152-9 (1987) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
RENI_RAT | Ren | Ren1
Type:
PROTEIN
Mol. Mass.:
44272.67
Organism:
Rattus norvegicus
Description:
ChEMBL_222765
Residue:
402
Sequence:
MGGRRMPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREILEERGVDMTRISAEWGEFIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGIIVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRESHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
Inhibitor
Name:
BDBM50024165
Synonyms:
4-[2-(4-{1-[1-Benzyl-2-(3-methyl-butyrylamino)-2-oxo-ethylcarbamoyl]-butylamino}-3-hydroxy-6-methyl-heptanoylamino)-propionylamino]-3-hydroxy-6-methyl-heptanoic acid methyl ester | CHEMBL3142810
Type:
Small organic molecule
Emp. Form.:
C39H65N5O9
Mol. Mass.:
747.9615
SMILES:
CCC[C@H](N[C@@H](CC(C)C)[C@@H](O)CC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)[C@@H](O)CC(=O)OC)C(=O)N[C@@H](Cc1ccccc1)C(=O)NC(=O)CC(C)C |r|