Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50023894
Substrate
n/a
Meas. Tech.
ChEMBL_53887 (CHEMBL668914)
IC50
60±n/a nM
Citation
 Rosowsky, A; Bader, H; Radike-Smith, M; Cucchi, CA; Wick, MM; Freisheim, JH Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate. J Med Chem 29:1703-9 (1986) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50023894
Synonyms:
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-phenylcarbamoyl-butyric acid | CHEMBL45735
Type:
Small organic molecule
Emp. Form.:
C25H25N9O4
Mol. Mass.:
515.5239
SMILES:
Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)Nc3ccccc3)C(O)=O)cnc2n1
Structure:
Search PDB for entries with ligand similarity: