Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50024811
Substrate
n/a
Meas. Tech.
ChEBML_152596
Ki
350000±n/a nM
Citation
 Grunewald, GL; Markovich, KM; Sall, DJ Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT) J Med Chem 30:2191-208 (1988) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50024811
Synonyms:
8-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-ylamine | CHEMBL302285
Type:
Small organic molecule
Emp. Form.:
C12H12F3N
Mol. Mass.:
227.2256
SMILES:
N[C@@H]1CC2CC1c1c2cccc1C(F)(F)F |TLB:0:1:6.7:4,THB:11:6:4:1.2,8:7:4:1.2|
Structure:
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